Correlation Between Tumor Voxel Dose Response Matrix and Tumor biomarker Profile in Patients With Head and Neck Squamous Cell Carcinoma.
Radiotherapy and Oncology
BACKGROUND: We have developed a novel imaging analysis procedure that is highly predictive of local failure after chemoradiation in head and neck cancer. In this study we investigated whether any pretreatment biomarkers correlated with key imaging parameters.
METHODS: Pretreatment biopsy material was available for 28 patients entered into an institutional trial of adaptive radiotherapy in which FDG-PET images were collected weekly during treatment. The biopsies were immunohistochemically stained for CD44, EGFR, GLUT1, ALDH1, Ki-67 and p53 and quantified using image analysis. Expression levels were correlated with previously derived imaging parameters, the pretreatment SUV
RESULTS: The different parameters of the SUV
CONCLUSIONS: The pretreatment SUV
Yan A, Hanna A, Wilson TG, Deraniyagala R, Krauss DJ, Grzywacz VP, Yan D, Wilson GD. Correlation between tumor voxel dose response matrix and tumor biomarker profile in patients with head and neck squamous cell carcinoma. Radiother Oncol. 2021 Nov;164:196-201. doi: 10.1016/j.radonc.2021.09.027. Epub 2021 Oct 4. PMID: 34619238.