Title

Correlation between tumor voxel dose response matrix and tumor biomarker profile in patients with head and neck squamous cell carcinoma.

Document Type

Article

Publication Date

11-1-2021

Publication Title

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Abstract

BACKGROUND: We have developed a novel imaging analysis procedure that is highly predictive of local failure after chemoradiation in head and neck cancer. In this study we investigated whether any pretreatment biomarkers correlated with key imaging parameters.

METHODS: Pretreatment biopsy material was available for 28 patients entered into an institutional trial of adaptive radiotherapy in which FDG-PET images were collected weekly during treatment. The biopsies were immunohistochemically stained for CD44, EGFR, GLUT1, ALDH1, Ki-67 and p53 and quantified using image analysis. Expression levels were correlated with previously derived imaging parameters, the pretreatment SUV

RESULTS: The different parameters of the SUV

CONCLUSIONS: The pretreatment SUV

Volume

164

First Page

196

Last Page

201

DOI

10.1016/j.radonc.2021.09.027

ISSN

1879-0887

PubMed ID

34619238

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