Local control matters.
Translational andrology and urology
Men with high-risk localized prostate cancer (PC) represent an important patient population for whom treatment decisions are complex. Compared to the average patient they have greater risk of distant metastasis (DM) and eventual PC-specific mortality (PCSM). To some this raises the question of the impact of local recurrence in the natural history of the disease. A growing body of evidence clearly demonstrates that local control in PC improves DM-free survival (DMFS) and overall survival (OS).
Levitin RB, Hamstra DA. Local control matters. Transl Androl Urol. 2020 Jun;9(3):991-996. doi: 10.21037/tau-2020-06. PMID: 32676381; PMCID: PMC7354304.