Risk of Brain Arteriovenous Malformation Hemorrhage Before and After Stereotactic Radiosurgery.
Background and Purpose- Understanding the hemorrhage risks associated with brain arteriovenous malformations (AVMs) before and after stereotactic radiosurgery (SRS) is important. The aims of this multicenter, retrospective cohort study are to evaluate and compare the rates of pre- and post-SRS AVM hemorrhage and identify risk factors. Methods- We pooled AVM SRS data from 8 institutions participating in the International Radiosurgery Research Foundation. Predictors of post-SRS hemorrhage were determined using a multivariate logistic regression model. Pre- and post-SRS hemorrhage rates were compared using Fisher exact test. Ruptured and unruptured AVMs were matched in a 1:1 ratio using propensity scores, and their outcomes were compared. Results- The study cohort comprised 2320 AVM patients who underwent SRS. Deep AVM location (odds ratio, 1.86; 95% CI, 1.19-2.92; P=0.007), the presence of an AVM-associated arterial aneurysm (odds ratio, 2.44; 95% CI, 1.63-3.66; P
Ding D, Chen CJ, Starke RM, Kano H, Lee JYK, Mathieu D, Feliciano C, Rodriguez-Mercado R, Almodovar L, Grills IS, Kondziolka D, Barnett GH, Lunsford LD, Sheehan JP. Risk of Brain Arteriovenous Malformation Hemorrhage Before and After Stereotactic Radiosurgery. Stroke. 2019 Jun;50(6):1384-1391. doi: 10.1161/STROKEAHA.118.024230. Epub 2019 May 2. PMID: 31043153.