Improving dosimetric outcome for hippocampus and cochlea sparing whole brain radiotherapy using spot-scanning proton arc therapy.

Authors

Xuanfeng Ding, Beaumont Health
Jun Zhou, Beaumont Health
Xiaoqiang Li, Beaumont Health
Kevin Blas, Beaumont Health
Gang Liu, Beaumont Health
Yinan Wang, Beaumont Health
An Qin, Beaumont Health
Prakash Chinnaiyan, Beaumont Health
Di Yan, Beaumont Health
Craig Stevens, Beaumont Health
Inga Grills, Beaumont Health
Peyman Kabolizadeh, Beaumont Health

Document Type

Article

Publication Date

4-1-2019

Publication Title

Acta oncologica (Stockholm, Sweden)

Abstract

This feasibility study shows that Spot-scanning Proton Arc therapy (SPArc) is able to significantly reduce the dose to the hippocampus and cochlea compared to both Volumetric Modulated Arc Photon Therapy (VMAT) and the robust optimized Intensity Modulated Proton Therapy (ro-IMPT) plans in whole brain radiotherapy. Furthermore, SPArc not only improves plan robustness but could potentially deliver a treatment as efficient as ro-IMPT when proton system's energy layer switch time is less than 1 s.

Volume

58

Issue

4

First Page

483

Last Page

490

Recommended Citation

Ding X, Zhou J, Li X, Blas K, Liu G, Wang Y, Qin A, Chinnaiyan P, Yan D, Stevens C, Grills I, Kabolizadeh P. Improving dosimetric outcome for hippocampus and cochlea sparing whole brain radiotherapy using spot-scanning proton arc therapy. Acta Oncol. 2019 Apr;58(4):483-490. doi: 10.1080/0284186X.2018.1555374. Epub 2019 Jan 11. PMID: 30632851.

DOI

10.1080/0284186X.2018.1555374

ISSN

1651-226X

PubMed ID

30632851