Document Type

Article

Publication Date

12-1-2021

Publication Title

Foot & Ankle Surgery: Techniques, Reports & Caes

Abstract

Lymphoma involves malignancy of the lymphatic system which includes the spleen, thymus, bone marrow and lymph nodes. Diffuse large B-cell lymphoma (DLBCL) is an aggressive, rapidly-growing type of non-Hodgkin lymphoma (NHL). We present a case of an 18-year-old male who initially presented with right hindfoot pain and swelling. Initial radiographs revealed no osseous pathology that correlated with the area of pain and swelling. Magnetic resonance imaging (MRI) was obtained which revealed a large soft tissue mass surrounding the calcaneus with cortical erosion and complete marrow replacement of the calcaneus. Due to concern for malignancy, the patient underwent a fluoroscopic-guided biopsy of the calcaneus. The pathology report revealed large atypical lymphoid infiltrates that were positive for B-cell molecular markers, CD20 and PAX5, consistent with the diagnosis of B-cell lymphoma. Initial positron emission tomography (PET) scan demonstrated hypermetabolism at the right foot, right popliteal fossa and right inguinal region which was consistent with Diffuse Large B-cell lymphoma, Grade 3B, Stage I or II. The patient underwent 6 cycles of chemotherapy. The patient’s pain and swelling to the hindfoot had completely resolved and the patient remains in remission.

Volume

1

Issue

4

Comments

Mariano A, Fallat LM. Unusual presentation of diffuse large B-cell lymphoma involving the calcaneus: A case report. Foot Ankle Surgery: Techniqes, Reports & Cases, 2021 Dec 1; 1(4). doi: 10.1016/j.fastrc.2021.100102.

DOI

10.1016/j.fastrc.2021.100102

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