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Conference Proceeding

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Publication Title

Developmental Medicine and Child Neurology


Introduction: The effects of incobotulinumtoxinA on lower limb (LL) spasticity-related pain (SRP) over multiple treatment cycles (ICs) in children/adolescents (C/As) with cerebral palsy (CP) were analyzed using pooled data from three prospective phase 3 trials.

Patients and methods: C/As aged 2–17 years with CP-associated LL spasticity received incobotulinumtoxinA for 4 ICs. SRP was assessed with the Questionnaire on Pain caused by Spasticity (QPS) using C/A- (direct or via interviewer) and parent/caregiver (P/C)-completed LL modules. The pain population included all C/As with a key QPS item score >0 at baseline; post-baseline scores of 0 indicated complete pain relief.

Results: Data from 331 C/As and 841 P/Cs with data for at least one key QPS item were included. LL general SRP was reported by 178 C/As at baseline; 35.3%/49.4% of patients treated with incobotulinumtoxinA were pain-free by week 4 of IC1/IC4 (p

Conclusion: In addition to muscle tone regulation, incobotulinumtoxinA provides sustained pain relief across multiple ICs for children with CP and LL SRP, even when they were engaged in demanding tasks.




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