Physiology, Acetylcholinesterase

Authors

Amy Trang
Paras B. Khandhar, Corewell Health

Document Type

Article

Publication Date

1-8-2024

Publication Title

StatPearls

Abstract

Acetylcholinesterase (AChE) is a cholinergic enzyme primarily found at postsynaptic neuromuscular junctions, especially in muscles and nerves. It immediately breaks down or hydrolyzes acetylcholine (ACh), a naturally occurring neurotransmitter, into acetic acid and choline. The primary role of AChE is to terminate neuronal transmission and signaling between synapses to prevent ACh dispersal and activation of nearby receptors. AChE is inhibited by organophosphates and is an important component of pesticides and nerve agents.

Recommended Citation

Trang A, Khandhar PB. Physiology, Acetylcholinesterase. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 30969557.

Comments

Bookshelf ID: NBK539735

PubMed ID

30969557