Eosinophils are a useful morphologic marker to scrutinize plasma cells in endometrial polyps.
American Journal of Clinical Pathology
Chronic endometritis is characterized by presence of plasma cells, which can be confirmed by immune-staining for CD138. Endometrial polyps can irritate endometrium and harbor some plasma cells. As eosinophils are much easier to be identified than plasma cells on hematoxylin and eosin stained sections, the goal of this study was to investigate if the identification of eosinophils in endometrial polyps was useful to alert us for looking for plasma cells more carefully.
Twenty-eight (28) endometrial polyp cases were retrospectively selected and eosinophils and plasma cells were searched microscopically. Cases with eosinophils and/or plasma cells found per high power filed were further stained for CD138.
Results (if a Case Study enter NA)
There were 8 cases with positive eosinophils (eosinophil group) and 18 cases without eosinophils (negative group). Age from eosinophil group ranged from 32 to 54 years old and the negative group has ages ranged from 32 to 72 years old. In eosinophil group, six of eight (6/8) cases in eosinophil group was correlated with positive CD138 positive plasma cells (ranging from 2 to 24 per high power field), whereas 2/8 cases had 1 eosinophil without confirmed CD138+ plasma cells. Negative group without eosinophils had no plasma cells identified.
Our data indicate that eosinophils can be an easy target for the next step to scrutinize plasma cells in endometrial polyps, thus promoting an accurate evaluation of chronic endometritis.
Afolayan-Oloye O, Anderson J, Zhang P. Eosinophils are a useful morphologic marker to scrutinize plasma cells in endometrial polyps. Am J Clin Pathol. 2022 Nov; 158(Suppl 1):S83. doi: 10.1093/ajcp/aqac126.172.