A suspected case of falsely low digoxin and vancomycin concentrations caused by free kappa light chains with PETINIA method.

Document Type

Article

Publication Date

4-28-2022

Publication Title

Practical laboratory medicine

Abstract

Vancomycin and digoxin are associated with potential toxicity and serum concentrations need to be monitored in certain patients. Previous reports suggested IgM paraproteins could interfere with vancomycin assays, and no paraprotein interference has been reported with digoxin assays. Here we present a suspected case of free-kappa light chains-mediated falsely low digoxin and vancomycin concentrations with Abbott particle-enhanced turbidimetric inhibition immunoassay (PETINIA) method. A 53-year-old patient received multiple doses of vancomycin and digoxin intravenously, but trough vancomycin and random digoxin concentrations repeatedly measured as

Volume

30

First Page

e00277

DOI

10.1016/j.plabm.2022.e00277

ISSN

2352-5517

PubMed ID

35541501

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