Pancreatic Ganglioneuroma Presenting in an Octogenarian.
ACG case reports journal
Pancreatic ganglioneuromas occur mostly in children and rarely in young adults, with no cases reported in adults older than 60 years. An 86-year-old-woman, with active advanced multiple myeloma, presented with epigastric pain for 2 days. Abdominal and pelvic computed tomography demonstrated a distended gallbladder, mildly dilated biliary tree, and a 13 × 8-mm hypodense mass in pancreatic body, without extrapancreatic invasion at endoscopic ultrasound. Fine-needle endoscopic ultrasound-guided core biopsy revealed characteristic histopathology of ganglioneuroma, as confirmed by immunohistochemical positivity for S100, SOX-10, and synaptophysin. This demonstrates novel finding of pancreatic ganglioneuroma occurring in the elderly. Lesion inclusion in the differential diagnosis may mandate tissue for pathologic diagnosis and complete lesion resection.
Shaheen AA, Gill I, Edhi AI, Amin M, Cappell MS. Pancreatic Ganglioneuroma Presenting in an Octogenarian. ACG Case Rep J. 2021 Mar 19;8(3):e00546. doi: 10.14309/crj.0000000000000546. PMID: 33763500; PMCID: PMC7984837.