Articular Cartilage Surface Roughness As An Imaging-Based Morphological Indicator of Osteoarthritis: A Preliminary Investigation of Osteoarthritis Initiative Subjects.
Current imaging-based morphometric indicators of osteoarthritis (OA) using whole-compartment mean cartilage thickness (MCT) and volume changes can be insensitive to mild degenerative changes of articular cartilage (AC) due to areas of adjacent thickening and thinning. The purpose of this preliminary study was to evaluate cartilage thickness-based surface roughness as a morphometric indicator of OA. 3D magnetic resonance imaging (MRI) datasets were collected from osteoarthritis initiative (OAI) subjects with Kellgren-Lawrence (KL) OA grades of 0, 2, and 4 (n = 10/group). Femoral and tibial AC volumes were converted to two-dimensional thickness maps, and MCT, arithmetic surface roughness (S
Newton MD, Osborne J, Gawronski K, Baker KC, Maerz T. Articular cartilage surface roughness as an imaging-based morphological indicator of osteoarthritis: A preliminary investigation of osteoarthritis initiative subjects. J Orthop Res. 2017 Dec;35(12):2755-2764. doi: 10.1002/jor.23588. Epub 2017 May 23. PubMed PMID: 28460415.