Stem Cell Therapies, Gene-Based Therapies, Optogenetics, and Retinal Prosthetics: Current State and Implications for the Future
Retina (Philadelphia, Pa.)
PURPOSE: To review and discuss current innovations and future implications of promising biotechnology and biomedical offerings in the field of retina. We focus on therapies that have already emerged as clinical offerings or are poised to do so.
METHODS: Literature review and commentary focusing on stem cell therapies, gene-based therapies, optogenetic therapies, and retinal prosthetic devices.
RESULTS: The technologies discussed herein are some of the more recent promising biotechnology and biomedical developments within the field of retina. Retinal prosthetic devices and gene-based therapies both have an FDA-approved product for ophthalmology, and many other offerings (including optogenetics) are in the pipeline. Stem cell therapies offer personalized medicine through novel regenerative mechanisms but entail complex ethical and reimbursement challenges.
CONCLUSION: Stem cell therapies, gene-based therapies, optogenetics, and retinal prosthetic devices represent a new era of biotechnological and biomedical progress. These bring new ethical, regulatory, care delivery, and reimbursement challenges. By addressing these issues proactively, we may accelerate delivery of care to patients in a safe, efficient, and value-based manner.
Wood EH, Tang PH, De la Huerta I, Korot E, Muscat S, Palanker DA, Williams GA. Stem Cell Therapies, Gene-Based Therapies, Optogenetics, and Retinal Prosthetics: Current State and Implications for the Future. Retina. 2019 May;39(5):820-835. doi: 10.1097/IAE.0000000000002449. PMID: 30664120; PMCID: PMC6492547.