Late-onset uveitis-glaucoma-hyphema syndrome caused by Soemmering ring cataract.
Canadian Journal of Ophthalmology. Journal Canadien d'ophtalmologie
OBJECTIVE: To propose a late-onset mechanism for uveitis-glaucoma-hyphema (UGH) syndrome caused by Soemmering ring cataract (SRC) and describe surgical outcomes.
DESIGN: Retrospective interventional case series.
PARTICIPANTS: Patients developing UGH from anterior displacement of a haptic from a SRC.
METHODS: A retrospective chart review was conducted of all patients referred to an anterior segment surgeon (J.C.H.) for intraocular lens (IOL) reposition/exchange between January 2003 and June 2017. Inclusion criteria consisted of all eyes with (i) a diagnosis of UGH syndrome, and (ii) SRC causing anterior displacement of a sulcus-fixated haptic with iris-haptic touch. Outcome measures were change in best corrected visual acuities (BCVA) and resolution of UGH findings.
RESULTS: Seven eyes of 7 patients developed UGH secondary to a SRC causing contact between the IOL optic/haptic and the iris/uvea. Diagnosis of UGH was made at a mean 9.1 years after IOL implantation; this was statistically different compared with UGH eyes with other mechanisms from our full UGH cohort (mean 5.4 years; p = 0.0367). The mean preoperative LogMAR BCVA of 0.45 improved to 0.37 after surgical intervention (p = 0.27). Resolution (or nearly full resolution) of UGH findings was achieved in all cases after SRC extraction and lens repositioning/exchange.
CONCLUSIONS: Late-onset UGH syndrome can be caused by SRC. Surgical removal of the SRC with IOL repositioning within the capsular bag resolves most if not all components of UGH. Anterior segment ultrasound biomicroscopy is a helpful modality for determining if a SRC is present by demonstrating anatomic relationships commonly obscured by a miotic pupil.
Cheung AY, Price JM, Hart JC Jr. Late-onset uveitis-glaucoma-hyphema syndrome caused by Soemmering ring cataract. Can J Ophthalmol. 2019 Aug;54(4):445-450. doi: 10.1016/j.jcjo.2018.09.001. Epub 2018 Nov 26. PMID: 31358142.