Systemic lymphoma masquerading as Vogt-Koyanagi-Harada syndrome: Report of a case with multimodal imaging and histopathology.
American Journal of Ophthalmology Case Reports
Purpose: To report a case of systemic diffuse large B cell lymphoma presenting with ocular manifestations and neurologic findings resembling Vogt-Koyanagi-Harada syndrome.
Observations: A 51-year-old Caucasian man presented with headache, ear pain, and blurry vision in both eyes. He was found to have bilateral exudative retinal detachments. After a short period of initial improvement with high dose systemic corticosteroid, his condition significantly worsened. An extensive work-up, including a kidney biopsy, led to a diagnosis of systemic diffuse large B cell lymphoma. He had excellent recovery following treatment with appropriate chemotherapy.
Conclusions and Importance: Systemic malignancy may present with ocular manifestations and may masquerade as another diagnosis. An unexpected clinical course may suggest an alternative diagnosis. A broad systemic work-up including an evaluation for malignancy should be considered for patients presenting with unexplained exam or systemic findings.
Moussa K, Begaj T, Ma K, Barrantes PC, Eliott D, Sobrin L. Systemic lymphoma masquerading as Vogt-Koyanagi-Harada syndrome: report of a case with multimodal imaging and histopathology. Am J Ophthalmol Case Rep. 2022 Jun 28;27:101643. doi: 10.1016/j.ajoc.2022.101643. PMID: 35800404.