Autologous Retinal Transplantation as a Primary Treatment for Large Chronic Macular Holes.
Retina (Philadelphia, Pa.)
PURPOSE: To report the outcomes of autologous neurosensory retinal transplant as a primary treatment for patients with large chronic macular holes and evaluate the safety and feasibility of the procedure.
DESIGN: Retrospective study, consecutive case series.
METHODS: We reviewed seven patients with a primary chronic large macular hole, who underwent autologous neurosensory retinal transplant. Mean preoperative minimum and maximum hole diameters were 643 µm and 1214 µm, respectively. Changes in visual acuity were measured postsurgery, and optical coherence tomography, fluorescein angiography, and microperimetry-3 were analyzed after the procedure.
RESULTS: Closure of the macular hole was achieved in all seven eyes in the study. At 1 year post-surgery, there was significant improvement in mean visual acuity (LogMAR 1.10 vs. 0.68, P = 0.001). Optical coherence tomography showed that all grafts had formed attachments to the retinal epithelial cells of the recipient retina. Mean preoperative ellipsoid zone defect was 1,089 ± 403.8 µm (range, 918-1,329 µm) which further decreased to 921 ± 129.1 µm (range, 670-1,201 µm) at final follow up (P = 0.09). Microperimetry-3 testing indicated retinal sensitivity in the graft in five eyes.
CONCLUSION: Autologous retinal transplantation may help rebuild the macular structure resulting in functional improvement for eyes with primary chronic large macular hole.
Tanaka S, Inoue M, Inoue T, Yamakawa T, Uchio E, Grewal DS, Mahmoud TH, Kadonosono K. Autologous Retinal Transplantation as a Primary Treatment for Large Chronic Macular Holes. Retina. 2020 Oct;40(10):1938-1945. doi: 10.1097/IAE.0000000000002693. PMID: 31800464.