Integrated Proteomic and Metabolomic prediction of Term Preeclampsia.
Term preeclampsia (tPE), ≥37 weeks, is the most common form of PE and the most difficult to predict. Little is known about its pathogenesis. This study aims to elucidate the pathogenesis and assess early prediction of tPE using serial integrated metabolomic and proteomic systems biology approaches. Serial first- (11-14 weeks) and third-trimester (30-34 weeks) serum samples were analyzed using targeted metabolomic (
Bahado-Singh R, Poon LC, Yilmaz A, Syngelaki A, Turkoglu O, Kumar P, Kirma J, Allos M, Accurti V, Li J, Zhao P, Graham SF, Cool DR, Nicolaides K. Integrated Proteomic and Metabolomic prediction of Term Preeclampsia. Sci Rep. 2017 Nov 23;7(1):16189. doi: 10.1038/s41598-017-15882-9. PubMed PMID: 29170520; PubMed Central PMCID: PMC5700929.