Neurosarcoidosis Presenting WIth Panhypopituitarism

Document Type

Conference Proceeding

Publication Date

10-2023

Publication Title

Journal of the Endocrine Society

Abstract

Introduction: Neurosarcoidosis is estimated to occur in approximately 5-15% patients with sarcoidosis. Pituitary involvement may be present in up to 5% of those cases and can manifest as hypothalamus, adenohypophysis dysfunction or arginine vasopressin deficiency (AVP-D) in isolated fashion or variedly combined. Clinical case: 32 year old male presented with chief complaint of worsening bilateral lower extremity weakness, urinary incontinence, polyuria and polydipsia. 9 months prior to admission the patient was diagnosed with neurosarcoidosis. At that time brain MRI showed diffuse leptomeningeal enhancement, chest CT showed hilar lymphadenopathy, lumbar puncture with CSF analysis showed protein 227 mg/dl (N13.2), urine osmolality of 72 mOsmol/kg, blood osmolality of 297 mOsmol/kg (N

Volume

7

Issue

Suppl 1

First Page

A724

Comments

Endocrine Society's Annual Meeting, ENDO 2023, June 15-18, 2023, Chicago, IL

DOI

10.1210/jendso/bvad114.1357

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