Refractory Acute Interstitial Nephritis in the Setting of Nivolumab Therapy.
Case Reports in Nephrology
A 65-year-old male patient with metastatic CCRCC developed steroid-dependent, grade 3 AIN secondary to nivolumab weeks after its initiation that resulted in 3 hospitalizations with acute renal failure. The patient was started on MM and his AIN was successfully controlled after a 2-year period of follow-up. Refractory renal AIN resulting from PD-1 inhibitor use is rare, and its successful treatment with mofetil mycophenolate with a 2-year follow-up in a patient with metastatic CCRCC has not been reported. This case is important because not only was his renal irAEs controlled but also long-term treatment with MM did not result in progression of metastatic disease.
Faieta A, Dancik T. Refractory Acute Interstitial Nephritis in the Setting of Nivolumab Therapy. Case Rep Nephrol. 2021 Mar 1;2021:6640154. doi: 10.1155/2021/6640154. PMID: 33728076; PMCID: PMC7939740.