Association of metabolomic biomarkers with sleeve gastrectomy weight loss outcomes

Authors

Wendy Miller, Beaumont Health
Kathryn Ziegler, Beaumont Health
Stewart Graham, Beaumont Health
Michael Maddens, Beaumont Health
Matthew Sims, Beaumont Health

Document Type

Conference Proceeding

Publication Date

11-4-2020

Publication Title

Obesity

Abstract

Background: Factors influencing weight loss variability following sleeve gastrectomy (SG) are not well understood. We evaluated the correlation of metabolomic biomarkers with weight loss outcomes. Methods: This prospective study evaluated the metabolomic profile of feces and serum prior to SG and three months post-SG, along with weight loss outcomes at three months post-SG (N=45). Serum and fecal samples were quantitatively profiled using a combination of 1H NMR and DI-LC-MS/MS (AbsoluteIDQ P180 kit (Biocrates, Innsbruck)). Results: Percent total weight loss (%TWL) for the lowest versus the highest weight loss tertiles (T1 vs T3) was 11.1 + 0.8% and 17.0 + 1.3%, p

Volume

28

Issue

Supplement S2

First Page

52

Last Page

53

Recommended Citation

Miller W, Ziegler K, Graham S, Maddens M, Sims M. Association of Metabolomic Biomarkers With Sleeve Gastrectomy Weight Loss Outcomes. In OBESITY 2020 Nov 1 (Vol. 28, pp. 52-53).