Multicenter Evaluation of the Unyvero Platform for Testing Bronchoalveolar Lavage Fluid.

Matthias Klein
Johannes Bacher
Sandra Barth
Faranak Atrzadeh
Katja Siebenhaller
Ines Ferreira
Sephan Beisken
Andreas E Posch
Karen C Carroll
Richard G Wunderink
Chao Qi
Fann Wu
Dwight J Hardy
Robin Patel
Matthew D Sims, Beaumont Health


Bronchoalveolar lavage (BAL) culture is a standard, though time-consuming, approach for identifying microorganisms in patients with severe lower respiratory tract (LRT) infections. The sensitivity of BAL culture is relatively low, and prior antimicrobial therapy decreases the sensitivity further, leading to overuse of empirical antibiotics. The Unyvero LRT BAL Application (Curetis GmbH, Germany) is a multiplex molecular panel that detects 19 bacteria, 10 antibiotic resistance markers, and a fungus,