Ulcerative Colitis Mortality Rate Trends the United States: Two-Decade Analysis Based on US Death Certificates

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Conference Proceeding

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Publication Title

American Journal of Gastroenterology


Introduction: Ulcerative Colitis (UC), a chronic condition causing inflammation in the bowel, considerably impacts the life quality and mortality of those suffering from it. This study thoroughly analyzes death rates related to UC across the United States over twenty years. By leveraging a comprehensive dataset derived from American death certificates, the research offers a vital understanding of the disease’s frequency, essential differences across demographic groups, and temporal patterns. Methods: This investigation utilized the CDC WONDER database to analyze mortality rate trends from 1999 to 2021, with a special emphasis on deaths due to Ulcerative Colitis. The study specifically focused on scrutinizing all recorded fatalities linked to UC in the United States within this period. R 4.2.2 software was the primary tool for conducting the analytical processes and creating data visualizations. All graphical illustrations were generated using the ggplot2 package within this software. Results: The overall mortality rate per 100,000 people slightly increased from 0.11 in 1999 to 0.13 in 2021. The data, categorized based on gender, revealed a slightly higher mortality rate in females than males throughout the study period. By 2021, the female mortality rate was 0.15 compared to the male rate of 0.11. White individuals consistently showed a higher mortality rate, reaching a peak of 0.16 in 2021. The mortality rate for Black or African American individuals was relatively lower, with a slight rise to 0.07 in 2021. The age-specific data revealed a trend of increasing mortality rate with increasing age. There were very few data points for the Asian or Pacific Islander population and the 25-34 age group; hence, no definitive trends could be deduced. The data categorized based on Hispanic origin showed that the mortality rate was typically lower in the Hispanic or Latino group compared to the Non-Hispanic or Latino group, with 2021 rates at 0.05 and 0.15, respectively (Table 1). Conclusion: To sum up, the research highlights an overall increase in the death rates from Ulcerative Colitis in the United States over the last twenty years, with noticeable differences found among various groups based on sex, race, and age. This study will enhance our comprehension of the effects of Ulcerative Colitis and provide valuable insights for distributing resources, creating policies, and implementing targeted actions in the field of public health.





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American College of Gastroenterology Annual Scientific Meeting, October 20-25, 2023, Vancouver, Canada

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