Crohn's Disease Mortality Rates in the United States: Two Decades Analysis Based on US Death Certificates

Document Type

Conference Proceeding

Publication Date


Publication Title

American Journal of Gastroenterology


Introduction: Crohn’s disease, a chronic inflammatory bowel condition, significantly burdens those affected’s quality of life and mortality. This research provides a comprehensive evaluation of mortality rates associated with Crohn’s disease across the United States, spanning 2 decades. Utilizing a robust dataset extracted from US death certificates, this study aims to deliver crucial insights into the disease’s prevalence, significant demographic disparities, and temporal trends. Methods: This investigation utilized the CDC WONDER database to analyze mortality rate trends from 1999 to 2021, with a special emphasis on deaths due to Crohn’s disease (CD). The study specifically focused on scrutinizing all recorded fatalities linked to CD in the United States within this period. R 4.2.2 software was the primary tool for conducting the analytical processes and creating data visualizations. All graphical illustrations were generated using the ggplot2 package within this software. Results: A general increase can be observed in examining mortality rates associated with Crohn’s disease in the United States between 1999 to 2021. The overall mortality rate rose from 0.18 per 100,000 in 1999 to 0.23 per 100,000 in 2021. Notably, the total number of deaths due to Crohn’s disease has also seen a rise from 501 in 1999 to 758 in 2021. In terms of gender, female mortality rates consistently surpassed those of males throughout the study period. In 2021, the female rate stood at 0.26 compared to the male rate of 0.20. Racial disparities were evident, with Whites having the highest mortality rates (0.27 in 2021), followed by Blacks or African Americans (0.14 in 2021). Mortality rates for other racial groups were not consistently reported, limiting comprehensive comparison. There was a slight variation in mortality rates by Hispanic origin. In 2021, the rate for those of Hispanic or Latino origin was 0.04, compared to 0.27 for those not of Hispanic or Latino origin (Figure 1, Table 1). Conclusion: The study reveals a general upward trend in Crohn’s disease mortality rates in the United States over the past 2 decades, with significant disparities evident across gender, racial, and age groups. This work will contribute to a more nuanced understanding of Crohn’s disease’s impact and offer strategic guidance for resource allocation, policy-making, and targeted interventions in the realm of public health.





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American College of Gastroenterology Annual Scientific Meeting, October 20-25, 2023, Vancouver, Canada