What are the benefits and harms of vitamin D for people with asthma?

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Cochrane Clinical Answers


High‐ to moderate‐certainty evidence shows that in adults and children with mild to moderate asthma, oral vitamin D does not reduce exacerbations requiring steroids or the number of people with asthma exacerbations requiring emergency department visits, hospitalizations, or both compared with placebo. Furthermore, there was little to no difference between groups in per cent of predicted forced expiratory volume in one second (FEV1) (high‐certainty evidence) or in scores on the Asthma Control Test (ACT) or the Childhood Asthma Control Test (C‐ACT) (moderate‐certainty evidence). Vitamin D did not increase the numbers of withdrawals from the study or serious adverse reactions from any cause. No trials reported a fatal asthma event (low‐certainty evidence).



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