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  Multiple Endocrine Neoplasia Type 1 in a Young Man With Seizures

  Nitya Batra, Nishant Aggarwal, Shailesh Niroula, Daniel Misra, Peter Czako, and Daniel Shelden

  Publication Date: 10-2022

  Introduction

  Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder involving mutation of the MEN1 gene. Clinically it is defined by tumors of the pituitary, parathyroid, and the entero-pancreatic endocrine cells. Other tumors have been associated with MEN1. We present a case of a previously healthy young man presenting with seizures.

  Discussion

  We present a classic case of MEN1 in a patient with significant family history with the presence of primary hyperparathyroidism, pituitary microadenoma, and duodenopancreatic NETs. • Interestingly, rare presentation of MEN1 as refractory seizures have been reported secondary to hyperinsulinemic hypoglycemia, but our patient was euglycemic with appropriate levels of insulin and C-peptide. This suggests an alternative etiology that is not well documented in available literature. • Given the complex and highly specialized skills needed to diagnose and treat MEN1, involvement of a multidisciplinary team is vital.

  Conclusion When the clinical suspicion for MEN1 is high, endocrinology evaluation with appropriate laboratory workup and targeted imaging of the typical endocrine organs as described for this patient are advised with careful multidisciplinary management and follow-up.

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  Urinary cytokines as potential biomarkers of mild cognitive impairment and Alzheimer’s disease: a pilot study

  Nazia Saiyed Saiyed, Ali Yilmaz, Sangeetha Vishweswariah, Sarah Bartolone, Tammy Osentoski, Stacey Ruff, Amita Pai, Michael Maddens, Khaled Imam, and Stewart F. Graham

  Publication Date: 10-21-2022

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  Impact of polycystic ovary syndrome on cardiovascular disease in obese female youth

  Collin R. Walentine, Michael R. Brennan, Kristen J. Nadeau, and Melanie Cree-Green

  Publication Date: 5-2-2022

  INTRODUCTION
  17% of youth in the United States are obese and the incidence is rising. Among obese adolescents, girls with polycystic ovary syndrome (PCOS) represent a vulnerable and understudied group. PCOS is strongly associated with dyslipidemia and cardiovascular disease (CVD) in adulthood, but studies of CVD in youth are limited. We hypothesized that obese youth with PCOS would show evidence of vascular dysfunction relative to girls with obesity without PCOS.