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Description

Cutaneous adverse drug reactions (CADR), also known as toxidermia, are skin manifestations resulting from systemic drug administration. These reactions range from mild erythematous skin lesions to life threatening desquamative disorders.

Epidermal desquamation is the highly regulated process of invisible shedding of corneocytes from the outermost layers of the stratum corneum. This occurs through the interplay between proteases and their inhibitors that control the degradation of corneodesmosomes.

Skin peeling is often encountered in dermatology and refers to exaggerated visible superficial desquamation which can occur in inherited and acquired conditions such as tinea infections, atopic dermatitis, immune disorders, and as a side effect of medications.

Ciprofloxacin is a fluoroquinolone antibiotic currently used to treat a broad range of bacterial infections. Ciprofloxacin has been shown to stimulate matrix degrading protease activity from fibroblasts and reduce collagen I synthesis.

Publication Date

5-4-2023

Disciplines

Dermatology

Comments

2023 Alvin Yarrows Research Day at Beaumont Hospital Farmington Hills, Farmington Hills, MI, May 4, 2023.

Ciprofloxacin Induced Palmar Desquamation

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