Squamous Cell Carcinoma Arising from a Tailgut Cyst: A Case Report Highlighting the Challenges of Diagnosis and Treatment

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Authors

Jacob Kalkman, Corewell Health West Resident
Roxanne Kyriakakis, Trinity Health

Description

Tailgut cysts (TGCs) are rare lesions caused by incomplete regression of the embryologic hindgut. These lesions are typically benign and incidentally noted on imaging studies. They may, however, cause mass-effect symptoms and do have the potential for malignant transformation. Squamous cell carcinoma (SCC) arising from a TGC is an extremely rare diagnosis. To date, only five prior case reports have been published. The gold standard of treatment is surgical resection with adjuvant radiation and chemotherapy on a case-by-case basis. The scarcity of the disease presents challenges when making treatment plans given the lack of clinical trials to guide therapy selection. As a result, we are dependent upon case studies to elucidate the optimal management plan. The goal of this study is to provide an additional data point regarding the treatment of SCC arising from a TGC.

Publication Date

5-9-2025

Disciplines

Surgery

Recommended Citation

Kalkman J, Kyriakaki R. Squamous cell carcinoma arising from a tailgut cyst: a case report highlighting the challenges of diagnosis and treatment. Presented at: Research Day Corewell Health West; 2025 May 9; Grand Rapids, MI.

Comments

2025 Research Day Corewell Health West, Grand Rapids, MI, May 9, 2025. Abstract 1810