Granular cell tumor of the colon presenting as profound weight loss
World Journal of Colorectal Surgery
Granular cell tumors (GCTs) are typically benign tumors of neuronal origin that stain positive for S-100. They traditionally occur in the skin and subcutaneous tissue with gastrointestinal tumor sites, such as the colon, being rare. On colonoscopy, they appear as a well-circumscribed, yellow, submucosal lesion. Biopsy prior to endoscopic or surgical removal can be inconclusive due to the submucosal nature of the lesion. Although GCTs are rarely malignant, they can metastasize with a high mortality rate. Endoscopic resection has been described as an appropriate treatment for tumors up to 5 cm in diameter. We present the case of a 19-year-old male who experienced a 60-pound weight loss, which was initially attributed to depression. On clinical examination, a GCT was found in his ascending colon.
Diaz S, Hain J, Hans S. Granular cell tumor of the colon presenting as profound weight loss. World Journal of Colorectal Surgery. 2020 Jan 1;9(1):14-14.