The contemporary use of intracoronary brachytherapy for instent restenosis: A review.

Luai Madanat, Beaumont Health Resident
Teodora Donisan, Beaumont Health Resident
Dinu V. Balanescu, Beaumont Health Resident
Ahmad Jabri
Ahmad Al-Abdouh
Sam Alsabti, Beaumont Health Resident
Shuo Li, Beaumont Health Resident
Mazhed Kheyrbek, Beaumont Health Resident
Amy Mertens
Ivan Hanson, Beaumont Health
Simon Dixon, Beaumont Health


In-stent restenosis (ISR) has been a major limitation in interventional cardiology and constitutes nearly 10 % of all percutaneous coronary interventions in the United States. Drug-eluting stent (DES) restenosis proves particularly difficult to manage and poses a high risk of recurrence and repeat intervention. Intra-coronary brachytherapy (IBT) has been traditionally viewed as a potential treatment modality for ISR. However, its use was hindered by procedural complexity, cost, and the advent of newer-generation DES. Recent data suggests promising results regarding IBT for the treatment of resistant DES-ISR. This review addresses the mechanism of action of IBT, procedural details, and associated risks and complications of its use. It will also highlight the available clinical evidence supporting the use of IBT and the future directions of its utilization in the treatment of ISR.