Severe Bradycardia and Down Syndrome

Document Type

Conference Proceeding - Restricted Access

Publication Date



Down syndrome, associated with trisomy in chromosome 21, is one of the most common genetic disorders. Cases of severe bradycardia and hypotension during sevoflurane induction have been reported with Down syndrome, even in those without congenital heart disease. This population may experience a dysfunction in autonomic cardiac regulation and sympathetic activation, hypothesized to be secondary to a decrease in cardiac cell volume. Our patient was a male with Down syndrome who presented for cataract surgery and subsequently became severely bradycardic after intubation. We will discuss the clinically significant findings that are common to patient’s with Down syndrome as well as the anesthetic considerations.


American Society of Anesthesiology Annual Meeting, San Diego, CA, October 9-11, 2021.