Use of Fresh Frozen Plasma and C1 Esterase Inhibitor in the Setting of Severe Agnioedema
We present a unique case of severe refractory angioedema and review treatment options after failure of conventional therapies. This is an 80 year old female with history of an amlodipine allergy who presented with an right MCA occlusion. A nicardipine infusion was given for hypertensive emergency followed by development of severe angioedema requiring intubation. All medications were transitioned to alternatives. Despite methylprednisolone, diphenhydramine, loratidine, and famotidine, angioedema remained with negative daily endotracheal tube cuff leaks. Multiple units of FFP were given followed by C1 esterase inhibitor. The patient ultimately required a tracheostomy and prolonged steroid course for 5 weeks.
Stevens J, Shakibai N, Asbahi MF. Use of fresh frozen plasma and C1 esterase inhibitor in the setting of severe angioedema. Presented at: American Society of Anesthesiologists Annual Meeting; 2023 Oct 14; San Francisco, CA.