Metabolomic serum profiling after ACL injury in rats: A pilot study implicating inflammation and immune dysregulation in post-traumatic osteoarthritis.

Authors

Tristan Maerz, Beaumont Health
Eric Sherman, Beaumont Health
Michael Newton, Beaumont Health
Ali Yilmaz, Beaumont Health
Praveen Kumar, Beaumont Health
Stewart F Graham, Beaumont Health
Kevin C Baker, Beaumont Health

Document Type

Article

Publication Date

7-1-2018

Publication Title

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Abstract

ACL rupture is a major risk factor for post-traumatic osteoarthritis (PTOA) development. Little information exists on acute systemic metabolic indicators of disease development. Thirty-six female Lewis rats were randomized to Control or noninvasive anterior cruciate ligament rupture (ACLR) and to three post-injury time points: 72 h, 4 weeks, 10 weeks (n = 6). Serum was collected and analyzed by

Volume

36

Issue

7

First Page

1969

Last Page

1979

Recommended Citation

Maerz T, Sherman E, Newton M, Yilmaz A, Kumar P, Graham SF, Baker KC. Metabolomic serum profiling after ACL injury in rats: A pilot study implicating inflammation and immune dysregulation in post-traumatic osteoarthritis. J Orthop Res. 2018 Jul;36(7):1969-1979. doi: 10.1002/jor.23854. Epub 2018 Feb 5. PMID: 29315787.

DOI

10.1002/jor.23854

ISSN

1554-527X

PubMed ID

29315787