Large Institutional Experience of Early Outcomes and Dosimetric Findings with Postoperative Stereotactic Partial Breast Irradiation in Breast Cancer.

Document Type

Article

Publication Date

2-2024

Publication Title

Radiotherapy and Oncology

Abstract

PURPOSE: To analyze the dosimetric and toxicity outcomes of patients treated with postoperative stereotactic partial breast irradiation (S-PBI).

METHODS: We identified 799 women who underwent S-PBI at our institution between January 2016 and December 2022. The most commonly used dose-fraction and technique were 30 Gy in 5 fractions (91.7 %) and a robotic stereotactic radiation system with real-time tracking (83.7 %). The primary endpoints were dosimetric parameters and radiation-related toxicities. For comparison, a control group undergoing ultra-hypofractionated whole breast irradiation (UF-WBI, n = 468) at the same institution was selected.

RESULTS: A total of 815 breasts from 799 patients, with a median planning target volume (PTV) volume of 89.6 cm

CONCLUSION: In this large cohort, S-PBI demonstrated favorable dosimetric and toxicity profiles. Considering the reduced radiation exposure to surrounding tissues, external beam PBI with advanced techniques should at least be considered over traditional WBI-based approaches for PBI candidates.

Volume

191

First Page

110066

Last Page

110066

DOI

10.1016/j.radonc.2023.110066

ISSN

1879-0887

PubMed ID

38142936

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