Identifying Prenatal Ultrasound Predictors and the Ideal Neonatal Management of Closing Gastroschisis: the Key is Prevention.
Journal of Perinatology
OBJECTIVE: To evaluate the optimal approaches to initial surgical management and the potential for prenatal ultrasound detection of patients with closing gastroschisis.
STUDY DESIGN: We performed a retrospective analysis of patients born with gastroschisis to determine clinical and surgical outcomes and the ability to determine prognosis by prenatal imaging. Data collected included operative findings and postoperative outcome, as well as prenatal imaging features from a subset of cases with and without closing gastroschisis. Statistical analyses were performed as appropriate.
RESULTS: We included 197 patients with gastroschisis. No statistical significance was seen in outcomes between closing gastroschisis patients undergoing resection versus intracorporeal parking (n = 18). Ultrasound review was performed on 33 of these patients, 11 with closing gastroschisis, and 22 without. Significantly more closing gastroschisis patients had imaging indicative of progressive defect narrowing and defect diameter ≤8 mm after 30 weeks of gestation versus non-closing patients (p = 0.002).
CONCLUSION: Parking of extruded bowel offers potential for intestinal remodeling. In addition, prenatal ultrasound may be useful in detection of closing gastroschisis in utero.
Field JP, Zuckerwise LC, DeMare AM, Zhao S, Lipscomb BE, Raees MA, Walia S, Lovvorn HN, Novotny NM. Identifying prenatal ultrasound predictors and the ideal neonatal management of closing gastroschisis: the key is prevention. J Perinatol. 2021 Dec;41(12):2789-2794. doi: 10.1038/s41372-021-01006-9. Epub 2021 Mar 31. PMID: 33790403.