The Severity of Obstructing Tubulopathy is Often Associated with Foci of Renal Tubular Obstruction

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Authors

Ping L. Zhang, Corewell Health
Hassan D. Kanaan, Corewell Health
Wei Li, Corewell Health

Description

Etiologies of renal failure due to renal tubular injury may result from either ischemic/toxic injury of proximal tubules (ATN), variants of interstitial nephritis or obstructing tubulopathy by the luminal blocking of either monoclonal casts, uric acid or calcified deposits. Our previous studies indicate that the polarizable semi-transparent calcium oxalate deposits block proximal tubules, whereas monoclonal casts, uric acid deposits and bluish calcium phosphates block the distal tubules. We hypothesized that the serum creatinine (SCr) levels and the number of tubular obstructing deposits were correlated so that pathologic identification of obstructing foci can be predictable for the extent of renal dysfunction.

Publication Date

10-2024

Keywords

renal, obstruction

Disciplines

Pathology

Recommended Citation

Zhang PL, Kanaan HD, Li W. The severity of obstructing tubulopathy is often associated with foci of renal tubular obstruction. Presented at: American Society of Nephrology (ASN) Kidney Week; 2024; Oct 23-27; San Diego CA.

Comments

American Society of Nephrology (ASN) Kidney Week, October 23-27, 2024, San Diego CA.