CD21 Stains Dendritic Networks in Tertiary Lymphoid Structure of Transplant Renal Biopsies to Avoid Misdiagnosis of Borderline Changes

Files

Authors

Brandon D. Metcalf, Corewell Health Resident
Wei Li, Corewell Health
Hassan Kanaan, Corewell Health
Ping L. Zhang, Corewell Health

Description

Tertiary Lymphoid Structures (TLS) have been described as germinal center-like lymphoid structures composed dendritic network, mixed lymphocytes and high endothelial venules in internal organs following primary lymphoid organs (thymus and spleen) and secondary lymphoid structures (lymph nodes and native lymphoid structures along GI tract).

The TLS is mainly located at peri-glomeruli, peri-vascular areas or renal pelvis following inflammatory insults. A recent study indicates that TLS can been seen up to 19 % of protocol transplant renal biopsies (TRB) (JASN, 2022;33:186-200).

We hypothesize that CD21 staining can identify dendritic cells of TLS so that borderline changes are not over-diagnosed.

Publication Date

5-9-2024

Disciplines

Pathology

Recommended Citation

Metcalf BD, Li W, Kanaan H, Zhang PL. Cd21 stains dendritic networks in tertiary lymphoid structure of transplant renal biopsies to avoid misdiagnosis of borderline changes. Presented at Corewell Health Hospital Farmington Hills 2024 Alvin Yarrows Research Day; 2024 May 9; Farmington Hills, MI.

Comments

2024 Alvin Yarrows Research Day at Corewell Health Hospital Farmington Hills, Farmington Hills, MI, May 9, 2024.