Intranasally applied human olfactory mucosa neural progenitor cells migrate to damaged brain regions.

Document Type

Article

Publication Date

7-1-2022

Publication Title

Future Science OA

Abstract

Aim: To determine if intranasally administered olfactory mucosa progenitor cells (OMPCs) migrate to damaged areas of brain.

Materials & methods: Rowett Nude (RNU) adult rats were injured using the Marmarou model then 2 weeks later received intranasally-delivered human OMPC. After 3 weeks, rats were sacrificed and brain sectioned. The mean distances from the human OMPCs to markers for degenerative neuronal cell bodies (p-c-Jun+), axonal swellings on damaged axons (β-APP+) and random points in immunostained sections were quantified. One-way ANOVA was used to analyze data.

Results: The human OMPCs were seen in specific areas of the brain near degenerating cell bodies and damaged axons.

Conclusion: Intranasally delivered human OMPC selectively migrate to brain injury sites suggesting a possible noninvasive stem cell delivery for brain injury.

Volume

8

Issue

6

First Page

806

Last Page

806

DOI

10.2144/fsoa-2022-0012

ISSN

2056-5623

PubMed ID

35909995

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