A Pilot Study of Changes in Urinary Podocalyxin Levels during Normal Pregnancy and Labor.
Romanian journal of internal medicine = Revue roumaine de medecine interne
Introduction. Increased urinary podocalyxin, a surrogate marker of podocyte detachment, has been shown in preeclampsia and eclampsia, but there is a paucity of data of the effect of normal pregnancy on its urinary excretion. We aimed to describe these changes in this pilot study. Methods. Urine podocalyxin levels were measured in 115 pregnant women. Of these, 12 women were in the second trimester of gestation, 57 in the third trimester and 46 women were in labor. Results. The median [IQR] urinary podocalyxin levels were 0.81 [0.27, 3.68], 0.92 [0.44, 5.49] and 64.7 [30.5, 106.3] ng/mg creatinine in the second trimester, third trimester, and during labor, respectively (pConclusion. Urinary podocalyxin levels were low in normal pregnancies and increased significantly during labor and with hematuria.
De Franco YP, Segovia N, Marx YF, Hoxhaj R, Palacios CF. A pilot study of changes in urinary podocalyxin levels during normal pregnancy and labor. Rom J Intern Med. 2022 Sep 22;60(3):160-165. doi: 10.2478/rjim-2022-0007. PMID: 35522589.