Impact of PCI on Both Culprit and Non-Culprit Lesions Vs. PCI on Culprit-Only Lesions on Outcomes in an Urban Center

Document Type

Conference Proceeding

Publication Date

5-2025

Publication Title

Journal of the Society for Cardiovascular Angiography and Interventions

Abstract

Background: Percutaneous coronary intervention (PCI) strategies vary, with some patients undergoing PCI on both culprit and non-culprit lesions, while others receive PCI on culprit lesions only. This study compares the baseline characteristics and outcomes between these two approaches in an urban center. Methods: A retrospective analysis was conducted on 602 patients, with 29.73% receiving PCI on both culprit and non-culprit lesions and 70.27% receiving PCI on culprit lesions only. Baseline characteristics and clinical outcomes were assessed using odds ratios (OR). Results: Baseline characteristics were similar between groups, with no significant differences in most variables except hypertension (p=0.03). Discharge Outcomes showed no significant differences between groups in length of stay, major bleeding, blood transfusion, acute kidney injury (AKI), or major arrhythmias. Unadjusted analysis showed higher all-cause mortality in the dual PCI group at 30 days [uOR 2.4 (95% CI: 1.24-4.60); p=0.009), six months [uOR 2.30 (95% CI: 1.22-4.3); p=0.01] and one year [uOR 2.08 (95% CI: 1.16-3.72); p=0.014], but this was not significant after adjustment. No significant differences were observed in other outcomes, including recurrent ACS, CHF readmission, and re-intervention. Conclusions: PCI on both culprit and non-culprit lesions was associated with higher unadjusted mortality at 30 days, six months and one year compared to culprit-only PCI, but these differences were not significant after adjusting for baseline factors. Further studies are warranted to explore optimal PCI strategies in diverse populations.

Volume

4

Issue

5 Suppl

First Page

26

Comments

Society for Cardiovascular Angiography & Interventions SCAI 48th Annual Scientific Sessions, May 1-3, 2025, Washington, DC

Last Page

27

DOI

10.1016/j.jscai.2025.103186

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