Association Between Metabolic Syndrome, Its Components, and Knee Osteoarthritis in Premenopausal and Menopausal Women: A Pilot Study.
Document Type
Article
Publication Date
7-10-2022
Publication Title
Cureus
Abstract
OBJECTIVE: This pilot study aimed to determine the correlation of metabolic syndrome (MetS), its components, and increased LDL (low-density lipoprotein) and total cholesterol levels with osteoarthritis (OA). In addition, our goal was to establish the association between MetS and the degree of handicap measured by the Lequesne index of functionality and severity of knee osteoarthritis.
MATERIALS AND METHODS: The pilot study included 25 subjects with knee OA and 19 subjects without knee OA. All subjects were menopausal or premenopausal women. MetS was diagnosed according to the National Cholesterol Education Program, Adult Treatment Panel III. OA was diagnosed if Kellgren-Lawrence ≥ 2.
RESULTS: MetS was detected in 80% of subjects with OA. In the non-OA group, MetS was detected in 26% of subjects. The difference in MetS prevalence between the two groups was significant (p=0.000). The presence of each MetS component was significant in the OA group, except for central obesity, which presence was marginally significant (p=0.054). Prevalence of increased total (p=0.019) and LDL cholesterol (p=0.000) was also significant in the OA group. A significant difference between OA and the non-OA group was detected in the prevalence of all five MetS components (p=0.016). In the OA group, the Lequesne index of functionality and severity of knee osteoarthritis was not significantly altered between subjects with and without MetS.
CONCLUSION: Metabolic syndrome, its components, increased LDL, and total cholesterol are correlated with osteoarthritis in premenopausal and menopausal women. MetS is not correlated with the degree of handicap in the knee joint measured by the Lequesne index.
Volume
14
Issue
7
First Page
e26726
Recommended Citation
Nemet M, Blazin T, Milutinovic S, Cebovic T, Stanojevic D, Zvekic Svorcan J. Association between metabolic syndrome, its components, and knee osteoarthritis in premenopausal and menopausal women: a pilot study. Cureus. 2022 Jul 10;14(7):e26726. doi: 10.7759/cureus.26726. PMID: 35967163.
DOI
10.7759/cureus.26726
ISSN
2168-8184
PubMed ID
35967163