Risk Factors for Midline Catheter Failure: A Secondary Analysis of an Existing Trial.
Ther Clin Risk Manag
OBJECTIVE: While midline catheters (MCs) are considered to be a reliable form of vascular access, up to 25% of the placements culminate in failure. We aimed to explore risk factors for MC failure.
METHODS: We performed an analysis of existing randomized controlled trial data involving a comparison of two midline catheters. The study aimed to assess risk factors related to MC failure, including patient, procedure, catheter, and vein characteristics. Cox regression was used for univariable and multivariable analyses to evaluate the association between characteristics and MC failure.
RESULTS: Among 191 patients that were included in this secondary analysis, more patients were female (114/191 [59.7%]) and average age was 60.2 (SD = 16.7) years. Clinical indications for MC placement included antibiotics (60.7%), difficult venous access (32.5%), or both (6.8%). In a univariable Cox regression analysis, the increase in pulse rate (HR 1.02; 95% CI, 1.00-1.04;
CONCLUSION: Elevated pulse rate, decreased oxygen saturation level, temperature ≥38°C, and norepinephrine use were each associated with an increased risk of MC failure. These factors should be considered when selecting the most appropriate vascular access device for individual patients. Additionally, the cephalic vein insertion has the highest risk for MC failure and other access points could be preferentially considered.
Bahl A, Johnson S, Mielke N, Chen NW. Risk factors for midline catheter failure: A Secondary analysis of an existing trial. Ther Clin Risk Manag. 2022 Oct 7;8:999-1007. doi: 10.2147/TCRM.S383502. PMID: 36238957.