A Hematologic Disaster: A Case of Simultaneous Chronic Lymphocytic Leukemia and Acute Myeloid Leukemia
Document Type
Conference Proceeding - Restricted Access
Publication Date
5-9-2025
Abstract
Chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML) are distinct hematologic malignancies, and their simultaneous occurrence is exceedingly rare. CLL is a slow-progressing B-cell malignancy that often remains asymptomatic but may occasionally present with B symptoms or lymphocytosis. Conversely, AML is a rapidly progressive clonal disorder of myeloid precursors that commonly leads to marrow failure and systemic symptoms. Risk factors for AML include preexisting myeloproliferative disorders, prior chemotherapy, and toxic exposures. Concurrent diagnoses of AML and CLL represent less than 1% of cases and are associated with poor prognosis. This case underscores the diagnostic complexity posed by coexisting hematologic malignancies and highlights the need for vigilant surveillance in lymphoproliferative disorders.
Recommended Citation
Patel K, Alhaddadin R, DeJonge J, Do P, Haddad N. A hematologic disaster: a case of simultaneous chronic lymphocytic leukemia and acute myeloid leukemia. Presented at: Research Day Corewell Health West; 2025 May 9; Grand Rapids, MI.
Comments
2025 Research Day Corewell Health West, Grand Rapids, MI, May 9, 2025. Abstract 1749