Impact of Frailty on In-Hospital Outcomes of Elderly Patients With Takotsubo Cardiomyopathy

Document Type

Conference Proceeding

Publication Date

5-2025

Publication Title

Journal of the Society for Cardiovascular Angiography and Interventions

Abstract

Background: Takotsubo Cardiomyopathy (TCM), defined by transient left ventricular dysfunction, is often triggered by acute emotional/ physical stress. It is a recognized cause of acute coronary syndrome, especially in the elderly who are vulnerable due to comorbidities, including frailty- a condition of reduced functional reserve and increased stress susceptibility. Methods: A retrospective analysis of the National Inpatient Sample (2016-21) identified patients aged 65+ hospitalized with TCM using ICD-10 codes. Frailty was classified based on Johns Hopkins ACG frailty-defining diagnoses. Multivariable mixed-effects logistic regression identified predictors of in-hospital outcomes. Propensity score matching was applied to 736 pairs to control confounders and assess outcomes. Results: Frail patients had significantly high in-patient mortality (5.71 vs 1.09%, p < 0.001), cardiogenic shock (8.47 vs 4.70%, p=0.003), sudden cardiac arrest (3.12 vs 1.49%, p=0.037), and sepsis (2.85 vs 0.95%, p=0.008) others like acute stroke, pulmonary embolism, mechanical circulatory support, cardiac arrhythmia, acute kidney injury, perioperative myocardial Injury, and length of stay showed no significant difference. Conclusions: Understanding the importance of frailty in elderly in-patient population with TCM helps us in optimizing management strategies and improving patient outcomes. However, there is room for studies in addressing frailty to reduce adverse outcomes in elderly TCM patients.

Volume

4

Issue

5 Suppl

First Page

52

Comments

Society for Cardiovascular Angiography and Interventions SCAI 48th Annual Scientific Sessions, May 1-3, 2025, Washington, DC

Last Page

53

DOI

10.1016/j.jscai.2025.103364

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