Impact of Pulmonary Hypertension on Catheter Ablation for Atrial Fibrillation

Document Type

Conference Proceeding

Publication Date

5-2024

Publication Title

Heart Rhythm

Abstract

Background: Patients with atrial fibrillation (AF) and concomitant pulmonary hypertension (pHTN) have an increased risk of morbidity and mortality. However, the outcomes of catheter ablation in this cohort are unclear. Objective: We compared the outcomes of catheter ablation in patients with AF and underlying pHTN to those without pHTN. Methods: The National Readmission Database (NRD) from 2016-2020 was used to identify patients with AF and pHTN who underwent AF ablation using appropriate ICD-10 codes. The primary outcome was AF readmission at 11 months. Secondary outcomes were heart failure (HF) readmissions, readmission related mortality, and all-cause re-admissions at 11 months. Cox proportional hazard regression was used to compare the outcomes between pHTN vs. no pHTN, and hazard ratios were calculated. Results: Out of 112,174 patients with AF who had an ablation, 10,144 had associated pHTN. On propensity-matched outcomes comparing with vs. without pHTN groups, there was no statistical difference in the primary endpoint of AF readmission [Hazard Ratio (HR) 5 0.93 (0.82-1.05); p50.25]. Secondary outcomes showed increased HF readmissions [HR 5 1.34 (1.25-1.45); p,0.0001], Readmission mortality [HR 5 1.22 (1.04-1.43); p50.01], and All-cause readmission [HR 5 1.08 (1.02-1.15); p50.008] among patients receiving AF Ablation with pHTN when compared to patients without pHTN at 11 months follow-up. Conclusion: Patients with pHTN undergoing catheter ablation for AF have an increased risk of HF readmissions, readmissions related mortality, and all-cause readmissions as compared to those without pHTN.

Volume

21

Issue

5S

First Page

S446

Comments

Heart Rhythm Society Annual Meeting, May 16-29, 2024, Boston, MA

Last Page

S447

DOI

10.1016/j.hrthm.2024.03.1182

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